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Identification of <i>PDE4D</i> as a Proliferation Promoting Factor in Prostate Cancer Using a <i>Sleeping Beauty</i> Transposon-Based Somatic Mutagenesis Screen

28 Apr 2009

Abstract excerpt

Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This study shows for the first time that the Sleeping Beauty transposon system can be used to identify candidate prostate...

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PMID: 19401450
DOI: 10.1158/0008-5472.can-08-3901

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