Article

GluN2A-mediated currents and calcium signal in human iPSC-derived neurons

2025-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Gene expression data indicate that during human brain development, neurons change the NMDA receptor (NMDAR) subunit composition to modulate their function, favouring the GluN2A subunit over GluN2B - a hallmark of neuronal maturation. However, evidence supporting this phenomenon in human iPSC-derived neurons remains elusive. Here, using two differentiation methods in parallel (BrainPhys Neuronal...

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Literature Corpus work: bbffac11-409b-5c97-8961-74cc497b5207
DOI: 10.1101/2025.09.26.678211

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