Article
Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Jun 2025
Netolicky Jakub, Zahumenska Petra, Misiachna Anna, Kolcheva Marharyta, Rehakova Kristyna, Hemelikova Katarina, Kortus Stepan, Langore Emily, Doderovic Jovana, Ladislav Marek, Korabecny Jan, Otyepka Michal, Srejber Martin, Horak Martin
Abstract excerpt
N-Methyl-d-aspartate receptors (NMDARs) play a crucial role in excitatory neurotransmission, with numerous pathogenic variants identified in the GluN subunits, including their ligand-binding domains (LBDs). The prevailing hypothesis postulates that the endoplasmic reticulum (ER) quality control machinery verifies the agonist occupancy of NMDARs, but this was tested in a limited number of studies. Using microscopy...
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