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Article

The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons.

Stem cell research - 1 Apr 2018

Neagoe Ioana, Liu Chang, Stumpf Alexander, Lu Yanmei, He Dongping, Francis Ross, Chen Jun, Reynen Paul, Alaoui-Ismaili Moulay Hicham, Fukui Hirokazu

Abstract excerpt

Abnormal signaling pathways mediated by N-methyl-d-aspartate receptors (NMDARs) have been implicated in the pathogenesis of various CNS disorders and have been long considered as promising points of therapeutic intervention. However, few efforts have been previously described concerning evaluation of therapeutic modulators of NMDARs and their downstream pathways in human neurons with endogenous expression of...

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PMID: 29454156
DOI: 10.1016/j.scr.2018.02.002

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