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Article

ATRX and DAXX: Mechanisms and Mutations.

Cold Spring Harbor perspectives in medicine - 1 Mar 2017

Dyer Michael A, Qadeer Zulekha A, Valle-Garcia David, Bernstein Emily

Abstract excerpt

Recent genome sequencing efforts in a variety of cancers have revealed mutations and/or structural alterations in ATRX and DAXX, which together encode a complex that deposits histone variant H3.3 into repetitive heterochromatin. These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAXX-mutant tumors. Interestingly, ATRX and DAXX...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28062559
DOI: 10.1101/cshperspect.a026567
PMCID: PMC5334245

Genes

ATRX
DAXX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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