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Article

Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms.

PloS one - 1 Jan 2013

Wood Thomas J, Thistlethwaite Angela, Harris Michael R, Lovell Simon C, Millar Catherine B

Abstract excerpt

The incorporation of histone variants into nucleosomes is a critical mechanism for regulating essential DNA-templated processes and for establishing distinct chromatin architectures with specialised functions. H2A.Z is an evolutionarily conserved H2A variant that has diverse roles in transcriptional regulation, heterochromatin boundary definition, chromosome stability and DNA repair. The H2A.Z C-terminus diverges...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24098487
DOI: 10.1371/journal.pone.0076394
PMCID: PMC3788105

Genes

INO80

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