Article

No evidence for aberrant expression of amyloid β and phosphorylated tau proteins in herpes simplex virus-infected human neurons <i>in vivo</i>

2021-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Increasing evidence implicates the neurotropic herpes simplex virus 1 (HSV-1) in the pathogenesis of Alzheimer’s Disease (AD). However, it is unclear whether previously reported findings in HSV-1 cell culture and animal models can be translated to humans. Here, we analyzed clinical specimens from latently HSV-1 infected individuals and individuals with lytic HSV infection of the brain (herpes si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbeaca60-57fb-571f-9d65-e9b6067d3ede
DOI: 10.1101/2021.09.24.461630

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

No evidence for aberrant expression of amyloid β and phosphorylated tau proteins in herpes simplex virus-infected human neurons <i>in vivo</i>DOI 10.1101/2021.09.24.461630Read

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cellsSemantic proximity Read

Herpes simplex virus type 1 and Alzheimerâ€™s disease: increasing evidence for a major role of the virusSemantic proximity Read

Simultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain TissueSemantic proximity Read

HSV-1 Infection Alters <i>MAPT</i> Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s DiseaseSemantic proximity Read

APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells.Semantic proximity Read

HSV, Axonal Transport and Alzheimer‘s Disease:in Vitroandin VivoEvidence for Causal RelationshipsSemantic proximity Read

Persistent Infection with Herpes Simplex Virus 1 and Alzheimer’s Disease—A Call to Study How Variability in Both Virus and Host may Impact DiseaseSemantic proximity Read

Viral Infection Induces Alzheimer’s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal ModelsSemantic proximity Read

CSF Biomarker Profiles in CNS Infection Associated with HSV and VZV Mimic Pattern in Alzheimer’s Disease.Semantic proximity Read

A 3D human brain–like tissue model of herpes-induced Alzheimer’s diseaseSemantic proximity Read

Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: Two Dimensional or Three Dimensional?Semantic proximity Read

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s DiseaseSemantic proximity Read