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Article

APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells.

PloS one - 15 Nov 2010

De Chiara Giovanna, Marcocci Maria Elena, Civitelli Livia, Argnani Rafaela, Piacentini Roberto, Ripoli Cristian, Manservigi Roberto, Grassi Claudio, Garaci Enrico, Palamara Anna Teresa

Abstract excerpt

Lifelong latent infections of the trigeminal ganglion by the neurotropic herpes simplex virus type 1 (HSV-1) are characterized by periodic reactivation. During these episodes, newly produced virions may also reach the central nervous system (CNS), causing productive but generally asymptomatic inf...

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Source

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Identifiers

PMID: 21085580
DOI: 10.1371/journal.pone.0013989
PMCID: PMC2981559

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21085580-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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