Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells

18 Jan 2012

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that remains latent in host neurons. Viral DNA replication is a highly structured process in which the redistribution of nuclear proteins plays an important role. Although tau is most widely known as a microtubule-associated protein found in a hyperphosphorylated state in the brains of patients with Alzheimer's disease (AD), this protein has also been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to HIV Research and Treatment
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22252837
DOI: 10.1002/jnr.23003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cellsPMID 22252837Read ↗

Phosphorylated-tau associates with HSV-1 chromatin and correlates with nuclear speckles decondensation in low-density host chromatin regionsSemantic proximity Read ↗

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's diseaseSemantic proximity Read ↗

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1Semantic proximity Read ↗

No evidence for aberrant expression of amyloid β and phosphorylated tau proteins in herpes simplex virus-infected human neurons <i>in vivo</i>Semantic proximity Read ↗

HSV-1 Infection Alters <i>MAPT</i> Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s DiseaseSemantic proximity Read ↗

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment.Semantic proximity Read ↗

Identification of nuclear tau isoforms in human neuroblastoma cells.Semantic proximity Read ↗

Microtubule-Associated Protein Tau Is Hyperphosphorylated during Mitosis in the Human Neuroblastoma Cell Line SH-SY5YSemantic proximity Read ↗

Abnormally phosphorylated tau in SY5Y human neuroblastoma cellsSemantic proximity Read ↗

Molecular Mechanism of Nuclear Tau Accumulation and its Role in Protein SynthesisSemantic proximity Read ↗

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in NeuronsSemantic proximity Read ↗

Simultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain TissueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.