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Isolation and characterization of a highly evolved type 3 vaccine-derived poliovirus in China.

Virus research - 15 Jun 2017

Zhang Xiaowei, Qin Chong, Li Wei, Zheng Zhenhua, Wang Hanzhong, Cui Zongqiang

Abstract excerpt

In this study, we report the identification and characterization of a highly evolved type 3 vaccine-derived poliovirus (VDPV) strain designated as WIV14, isolated in 2014 from a 4-year-old child suspected of having an enteroviral infection in China. Complete genome sequence of WIV14 revealed multiple nucleotide substitutions when compared with the attenuated poliovirus (PV) Sabin 3, including the reversion of...

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PMID: 28669764
DOI: 10.1016/j.virusres.2017.06.017

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