Article

First-in-human, phase 1, randomized, observer-blind, controlled trial to assess the safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults

2025-02-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Reducing the risks of vaccine-derived polioviruses and vaccine-associated paralytic poliomyelitis from type 1 or 3 Sabin-strain oral poliovirus vaccines (OPVs) motivated the development of novel type 1 and 3 OPVs (nOPV1, nOPV3), designed to have similar safety and immunogenicity and improved genetic stability to reduce risk of reversion to neurovirulence. In this first-in-hu...

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Identifiers and source

Literature Corpus work: a8158723-1188-595a-9881-25829ca76bc4
DOI: 10.1101/2025.02.21.25322566

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