Article
Approaches to the construction of new candidate poliovirus type 3 vaccine strains.
Developments in biological standardization - 1 Jan 1993
Almond J W, Stone D, Burke K, Skinner M A, Macadam A J, Wood D, Ferguson M, Minor P D
Abstract excerpt
The World Health Organization has called for improvements to oral polio vaccines (OPV), particularly the type 3 component. Our improved understanding of the genetic basis of attenuation and antigenicity of this strain gives rise to possibilities for constructing new derivatives via mutagenesis of...
Topics
- Antibodies, Viral
- Antigens, Viral
- Base Sequence
- Genome, Viral
- Humans
- Molecular Sequence Data
- Mutation
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral
- Recombinant Proteins
- Temperature