Article
Approaches to the construction of new candidate poliovirus type 3 vaccine strains.
Developments in biological standardization - 1 Jan 1993
Almond J W, Stone D, Burke K, Skinner M A, Macadam A J, Wood D, Ferguson M, Minor P D
Abstract excerpt
The World Health Organization has called for improvements to oral polio vaccines (OPV), particularly the type 3 component. Our improved understanding of the genetic basis of attenuation and antigenicity of this strain gives rise to possibilities for constructing new derivatives via mutagenesis of infectious cDNA. This article reviews progress made with various approaches to constructing a new type 3 candidate...
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