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Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

23 Apr 2020

Abstract excerpt

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and limits poliovirus spread. Accordingly, vaccination with OPV is the primary strategy used to end the circulation of all polioviruses. However, the ability of OPV to regain replication fitness and establish new epidemics represents a...

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Identifiers

PMID: 32330425
DOI: 10.1016/j.chom.2020.04.003

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