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Article

Detection of Emerging Vaccine-Related Polioviruses by Deep Sequencing.

Journal of clinical microbiology - 1 Jul 2017

Sahoo Malaya K, Holubar Marisa, Huang ChunHong, Mohamed-Hadley Alisha, Liu Yuanyuan, Waggoner Jesse J, Troy Stephanie B, Garcia-Garcia Lourdes, Ferreyra-Reyes Leticia, Maldonado Yvonne, Pinsky Benjamin A

Abstract excerpt

Oral poliovirus vaccine can mutate to regain neurovirulence. To date, evaluation of these mutations has been performed primarily on culture-enriched isolates by using conventional Sanger sequencing. We therefore developed a culture-independent, deep-sequencing method targeting the 5' untranslated region (UTR) and P1 genomic region to characterize vaccine-related poliovirus variants. Error analysis of the...

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Identifiers

PMID: 28468861
DOI: 10.1128/JCM.00144-17
PMCID: PMC5483918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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