Article
Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
PloS one - 19 Jun 2009
Quaye Lydia, Tyrer Jonathan, Ramus Susan J, Song Honglin, Wozniak Eva, DiCioccio Richard A, McGuire Valerie, Høgdall Estrid, Høgdall Claus, Blaakaer Jan, Goode Ellen L, Schildkraut Joellen M, Easton Douglas F, Krüger-Kjaer Susanne, Whittemore Alice S, Gayther Simon A, Pharoah Paul D P
Abstract excerpt
BACKGROUND: Recent studies have identified several single nucleotide polymorphisms (SNPs) in the population that are associated with variations in the risks of many different diseases including cancers such as breast, prostate and colorectal. For ovarian cancer, the known highly penetrant susceptibility genes (BRCA1 and BRCA2) are probably responsible for only 40% of the excess familial ovarian cancer risks,...
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