Article

Patient-specific logical models replicate phenotype responses to psoriatic and anti-psoriatic stimuli

2023-08-26

Abstract excerpt

Psoriasis is a dermatologic disease that affects 2% of the world population. Psoriasis is characterized by chronic inflammation and aberrant behavior of keratinocytes, which display increased levels of proliferation, and decreased differentiation and apoptosis. Stimulation of keratinocytes by psoriatic cytokines leads to the increased production of immunostimulatory ligands that further attract immune cells and am...

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Literature Corpus work: bbbfc41b-7aa6-58ef-b8c9-21e2de46703b
DOI: 10.1101/2023.08.24.554583

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