Article

Meta-analysis of RNA sequencing data from 534 skin samples shows substantial IL-17 effects in non-lesional psoriatic skin

2023-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Psoriasis is a common chronic inflammatory skin disease characterized by disturbed interactions between infiltrating immune cells and keratinocytes. To enhance our understanding of the underlying molecular and cellular mechanisms driving psoriasis pathobiology, and to identify potential biomarkers for disease severity, we conducted RNA sequencing of skin biopsies from 75 patients with psoriasis v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3828a33b-efa6-5ddf-a86f-4ca322bf09dc
DOI: 10.1101/2023.11.03.23298021

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Meta-analysis of RNA sequencing data from 534 skin samples shows substantial IL-17 effects in non-lesional psoriatic skinDOI 10.1101/2023.11.03.23298021Read

Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patientsSemantic proximity Read

The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and KeratinizationSemantic proximity Read

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity Read

RNA sequencing of a large number of psoriatic patients identifies 131 novel miRNAs and 11 miRNAs associated with disease severitySemantic proximity Read

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skinSemantic proximity Read

Integrative single-cell transcriptomic investigation unveils long non-coding RNAs associated with localized cellular inflammation in psoriasisSemantic proximity Read

Transcriptomic meta-analysis in plaque psoriasis: an integrative bioinformatic approach to deciphering the genetic landscape and molecular pathwaysSemantic proximity Read

Single-cell transcriptome analysis identifies hub genes in Psoriatic SkinSemantic proximity Read

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the PathogenesisSemantic proximity Read

Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RNSemantic proximity Read

Modulation of Epidermal Transcription Circuits in Psoriasis: New Links between Inflammation and HyperproliferationSemantic proximity Read

Transcriptomic Profiling of Peripheral Edge of Lesions to Elucidate the Pathogenesis of Psoriasis VulgarisSemantic proximity Read