Article

Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes

2021-06-07

Abstract excerpt

Psoriasis is characterized by chronic inflammation, perpetuated by a Th17-dependent signaling loop between the immune system and keratinocytes that could involve phospholipase A 2 (PLA 2 )-dependent eicosanoid release. A prior knowledge network supported by experimental observations was used to encode the regulatory network of psoriatic keratinocytes in a computational model for studying the mode of action of a...

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Literature Corpus work: 05f97900-34ee-5b05-9e22-d514ef3f155a
DOI: 10.1101/2021.06.07.447313

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