Article

A dynamic Boolean model of molecular and cellular interactions represents psoriasis development and predicts drug candidates

2023-09-06

Abstract excerpt

Psoriasis is a chronic skin disease affecting 2-3% of the global population. Psoriasis arises from complex interactions between keratinocytes and immune cells, leading to uncontrolled inflammation, immune hyperactivation and perturbed keratinocyte life cycle. Although the latest generation of drugs have greatly improved psoriasis management, the disease remains incurable, and the substantial variability in treatme...

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Identifiers and source

Literature Corpus work: 64fed50e-7feb-5d9d-b537-7cc8a3cd2f10
DOI: 10.1101/2023.09.03.556147

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