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Transcriptome classification reveals molecular subtypes in psoriasis

12 Sept 2012

Abstract excerpt

BACKGROUND: Psoriasis is an immune-mediated disease characterised by chronically elevated pro-inflammatory cytokine levels, leading to aberrant keratinocyte proliferation and differentiation. Although certain clinical phenotypes, such as plaque psoriasis, are well defined, it is currently unclear whether there are molecular subtypes that might impact on prognosis or treatment outcomes. RESULTS: We present a...

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PMID: 22971201
DOI: 10.1186/1471-2164-13-472

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