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Article

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.

QJM : monthly journal of the Association of Physicians - 1 Feb 2026

Shou Yanhong, Zhu Ronghui, Wang Zhao-Yuan, Zhang Meijie, Man Xiao-Yong

Abstract excerpt

BACKGROUND: Most chronic skin diseases are classified as immune-mediated disorders, and targeted treatments, such as those blocking the cytokines IL-17, IL-23, IL-4/13, and the JAK-STAT pathway, have revolutionized therapy. However, a substantial proportion of patients fail to achieve remission and remain refractory to these therapies. METHODS: We meta-analyzed heterogeneous cell clusters in different...

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PMID: 41065508
DOI: 10.1093/qjmed/hcaf233

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