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Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems

2 Jun 2023

Abstract excerpt

Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context and systemic impact remain poorly understood. We thus profiled human psoriasis (PsO) as a prototypic immune-mediated condition with a high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses of 25 healthy, active lesion, and clinically uninvolved skin biopsies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37267384
DOI: 10.1126/sciimmunol.abq7991

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