Article

IL-33 protects from recurrent <i>C. difficile</i> infection by restoration of humoral immunity

2024-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Clostridioides difficile infection (CDI) recurs in one of five patients. Monoclonal antibodies targeting the virulence factor TcdB reduce disease recurrence, suggesting that an inadequate anti-TcdB response to CDI leads to recurrence. In patients with CDI, we discovered that IL-33 measured at diagnosis predicts future recurrence, leading us to test the role of IL-33 signaling in the induction of...

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Literature Corpus work: bbb2cfba-478e-50e4-88e8-a89e1c9ca9f9
DOI: 10.1101/2024.11.16.623943

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