Article

ENGINEERING AND PRECLINICAL EVALUATION OF DRIED FOOD-FORMULATED YEAST-SECRETED ANTIBODIES AS PERI-EXPOSURE PROPHYLAXIS AGAINST CLOSTRIDIOIDES DIFFICILE DISEASE

2025-11-15

Abstract excerpt

Clostridioides difficile gastrointestinal infection (CDI) causes significant disease burden, often following gut dysbiosis induced by antibiotic treatment in at-risk individuals. A non-invasive, easy to use targeted prophylaxis in such cases of acute elevated CDI risk, especially in those with a history of recurrent CDI, would prevent much suffering. In this study, we envisioned a simple prophylactic intervention...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 914c8a80-00ee-5c83-b631-c55f4e64c283
DOI: 10.1101/2025.11.14.688569

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ENGINEERING AND PRECLINICAL EVALUATION OF DRIED FOOD-FORMULATED YEAST-SECRETED ANTIBODIES AS PERI-EXPOSURE PROPHYLAXIS AGAINST CLOSTRIDIOIDES DIFFICILE DISEASEDOI 10.1101/2025.11.14.688569Read

IL-33 protects from recurrent C. difficile infection by restoration of humoral immunitySemantic proximity Read

Orally Antigen-Engineered Yeast Vaccine Elicits Robust Intestinal Mucosal ImmunitySemantic proximity Read

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivoSemantic proximity Read

Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection PreventionSemantic proximity Read

Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspectiveSemantic proximity Read

Engineered antibodies targeted to bacterial surface integrate effector functions with toxin neutralization to provide superior efficacy against bacterial infectionsSemantic proximity Read

An oral protein cocktail therapeutic for C. difficile infectionSemantic proximity Read

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatmentsSemantic proximity Read

Oral SARS-CoV-2 Spike Protein Recombinant Yeast Candidate Prompts Specific Antibody and Gut Microbiota Reconstruction in MiceSemantic proximity Read

A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infectionSemantic proximity Read

A monoclonal antibody collection for C. difficile typingSemantic proximity Read

Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB and CagA induce protection against Helicobacter pylori infection in miceSemantic proximity Read