Article

Propensity-Matched Case Control Study of Anti-Interleukin-23 Therapies in Clostridioides difficile Infection

2026-07-03

Abstract excerpt

<title>Abstract</title> <p> Background <italic>Clostridioides difficile</italic> infection remains a major cause of infectious morbidity and mortality, largely driven by a dysregulated, toxin-mediated host immune response that current pathogen-targeted therapies fail to address. Interleukin-23-driven Th17 responses and subsequent neutrophil activation play a major role in disease severity and intestinal injury...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 552783b4-2faf-5be3-b63b-ea51572448de
DOI: 10.21203/rs.3.rs-10060050/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Propensity-Matched Case Control Study of Anti-Interleukin-23 Therapies in Clostridioides difficile InfectionDOI 10.21203/rs.3.rs-10060050/v1Read

Pro-inflammatory Pathways Contribute to Pathogenesis of <i>Clostridioides difficile</i> Infection in a Murine Model - A Spatial Transcriptomics StudySemantic proximity Read

Antibiotics promote susceptibility to <i>C. difficile</i> infection through a CCR5-dependent immune responseSemantic proximity Read

Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients.Semantic proximity Read

Risk Factors for Clostridioides difficile Infection in Ulcerative Colitis: A Single-Center Case- Control StudySemantic proximity Read

A Computational Framework to Quantify Host-Microbiome Interactions in Clostridioides Difficile InfectionSemantic proximity Read

Integrating gut microbiome and host immune markers to understand the pathogenesis of Clostridioides difficile infectionSemantic proximity Read

IL-33 protects from recurrent <i>C. difficile</i> infection by restoration of humoral immunitySemantic proximity Read

Fecal microbiota transplantation increases colonic IL-25 and dampens tissue inflammation in patients with recurrent<i>Clostridioides difficile</i>Semantic proximity Read

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity Read

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records.Semantic proximity Read

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23Semantic proximity Read

Dermatologic disease in Inflammatory Bowel Disease: a 10-year, 401-patient cohort from a dedicated IBD– Dermatology ProgramSemantic proximity Read