Article

Development of a BiAD sensor for locus-specific detection of cellular histone acetylation dynamics by fluorescence microscopy

2025-02-12

Abstract excerpt

<h4>Summary</h4> Dynamic changes in histone acetylation play crucial roles during cellular differentiation and disease development. Here, we developed a Bimolecular Anchor Detector (BiAD) sensor for the detection of locus-specific changes in histone acetylation in living cells by fluorescence microscopy. For this, we used the BRD9 bromodomain cloned as tandem double-domain (2xBRD9-BD) as reader of histone acetyla...

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Literature Corpus work: bbad086c-dbf1-525a-81d5-1e7034f76a12
DOI: 10.1101/2025.02.10.637448

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