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Article

A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity.

Biochemistry - 22 Mar 2011

Lin Tianming, Greenberg Michael J, Moore Jeffrey R, Ostap E Michael

Abstract excerpt

myo1c is a member of the myosin superfamily that has been proposed to function as the adaptation motor in vestibular and auditory hair cells. A recent study identified a myo1c point mutation (R156W) in a person with bilateral sensorineural hearing loss. This mutated residue is located at the start of the highly conserved switch 1 region, which is a crucial element for the binding of nucleotide. We characterized...

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Identifiers

PMID: 21265502
DOI: 10.1021/bi1016777
PMCID: PMC3059334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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