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Article

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.

The Journal of biological chemistry - 1 Jan 2000

Jiang Fangfang, Takagi Yasuharu, Shams Arik, Heissler Sarah M, Friedman Thomas B, Sellers James R, Bird Jonathan E

Abstract excerpt

Cochlear hair cells each possess an exquisite bundle of actin-based stereocilia that detect sound. Unconventional myosin 15 (MYO15) traffics and delivers critical molecules required for stereocilia development and thus is essential for building the mechanosensory hair bundle. Mutations in the human MYO15A gene interfere with stereocilia trafficking and cause hereditary hearing loss, DFNB3, but the impact of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33372036
DOI: 10.1074/jbc.RA120.014903
PMCID: PMC7948958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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