Article
The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step.
The Journal of biological chemistry - 19 Jan 2018
Xiong Ailian, Haithcock Jessica, Liu Yingying, Eusner Lauren, McConnell Matthew, White Howard D, Belknap Betty, Forgacs Eva
Abstract excerpt
Mutations in the MYO7A gene, encoding the motor protein myosin VIIa, can cause Usher 1B, a deafness/blindness syndrome in humans, and the shaker-1 phenotype, characterized by deafness, head tossing, and circling behavior, in mice. Myosin VIIa is responsible for tension bearing and the transduction mechanism in the stereocilia and for melanosome transport in the retina, in line with the phenotypic outcomes...
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