Article
Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism.
Molecular biology of the cell - 1 Jan 2022
Gunther Laura K, Cirilo Joseph A, Desetty Rohini, Yengo Christopher M
Abstract excerpt
Class III myosins are actin-based motors proposed to transport cargo to the distal tips of stereocilia in the inner ear hair cells and/or to participate in stereocilia length regulation, which is especially important during development. Mutations in the MYO3A gene are associated with delayed onset deafness. A previous study demonstrated that L697W, a dominant deafness mutation, disrupts MYO3A ATPase and motor...
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