Article

Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFкB p50 recruitment, and H3K9me2 deposition

2022-02-10

Abstract excerpt

Cells must moderate transcription that is induced by virus infection to mitigate deleterious consequences of inflammation. We investigated the mechanisms whereby Keap1 moderates the transcription of genes that are induced by Sendai virus infection in mouse embryo fibroblasts (MEFs). Virus infection induced Keap1 to bind Ifnb1, Tnf and Il6 , and reduced Keap1 binding at Cdkn1a and Ccng1 . Keap1 was required for...

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Literature Corpus work: bb7c1ecf-27f7-5e45-8bf7-f310b58bc405
DOI: 10.1101/2022.02.08.479619

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