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Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation

27 Dec 2017

Abstract excerpt

The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. Inhibition of LSD1 was found to block viral genome transcription and lytic replication of DNA viruses. However, RNA virus genomes do not rely on chromatin structure and histone association, and the role of demethylase activity of LSD1 in RNA virus infections is not anticipated. Here, we identify...

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PMID: 29281729
DOI: 10.1371/journal.ppat.1006773

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