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Article

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

Cancer research - 1 Mar 2001

Pihan G A, Purohit A, Wallace J, Malhotra R, Liotta L, Doxsey S J

Abstract excerpt

Factors that determine the biological and clinical behavior of prostate cancer are largely unknown. Prostate tumor progression is characterized by changes in cellular architecture, glandular organization, and genomic composition. These features are reflected in the Gleason grade of the tumor and in the development of aneuploidy. Cellular architecture and genomic stability are controlled in part by centrosomes,...

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PMID: 11280789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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