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Article

Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential

7 May 2020

Abstract excerpt

BACKGROUND: Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previous studies have linked chromosomal instability (CIN), which generates aneuploidy following chromosomal missegregation during mitosis, to PC progression. Evidence of CIN includes broad copy number...

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PMID: 32380981
DOI: 10.1186/s12885-020-06817-1

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