Article
Microglial ablation does not affect opioid-induced hyperalgesia in rodents
2021-04-28
Abstract excerpt
Opioids are the frontline analgesics in pain management. However, chronic use of opioid analgesics causes paradoxical pain that contributes to the decrease of their efficacy in pain control and the escalation of dose in long-term management of pain. The underling pathogenic mechanism is not well understood. Microglia have been commonly thought to play a critical role in the expression of opioid-induced hyperalgesi...
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Identifiers and source
- Literature Corpus work
- bb4a4784-e796-5cf2-a1d2-6a330c9e7d35
- DOI
- 10.1101/2021.04.27.441650