Article

Linking Pain and Delirium via Microglial Activation: A Mouse Study Using BSEEG, Behavioral Assays, Immunohistochemistry, and RNA Sequencing

2025-10-31

Abstract excerpt

<h4>Background</h4> The rising incidence of delirium in surgical and critical care settings, especially in older patients, calls for improved preventative and management strategies. Chronic pain is increasingly recognized as a key risk factor for delirium, and microglial activation may be the central mediator linking these two conditions. <h4>Methods</h4> We used a spared nerve injury (SNI) model of persistent n...

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Literature Corpus work: 9031b1c7-0add-5b2a-aa69-524a42816f6e
DOI: 10.1101/2025.10.29.685463

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