Article
P2X4R+ microglia drive neuropathic pain.
Nature neuroscience - 26 Jul 2012
Beggs Simon, Trang Tuan, Salter Michael W
Abstract excerpt
Neuropathic pain, the most debilitating of all clinical pain syndromes, may be a consequence of trauma, infection or pathology from diseases that affect peripheral nerves. Here we provide a framework for understanding the spinal mechanisms of neuropathic pain as distinct from those of acute pain or inflammatory pain. Recent work suggests that a specific microglia response phenotype characterized by de novo...
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