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Article

BK channels in microglia are required for morphine-induced hyperalgesia.

Nature communications - 31 May 2016

Hayashi Yoshinori, Morinaga Saori, Zhang Jing, Satoh Yasushi, Meredith Andrea L, Nakata Takahiro, Wu Zhou, Kohsaka Shinichi, Inoue Kazuhide, Nakanishi Hiroshi

Abstract excerpt

Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hyperalgesia (MIH) and anti-nociceptive tolerance. Microglia-to-neuron signalling is critically involved in pain hypersensitivity. However, molecules that control microglial cellular state under chronic morphine treatment remain unknown. Here we show that the microglia-specific...

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Identifiers

PMID: 27241733
DOI: 10.1038/ncomms11697
PMCID: PMC4895018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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