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Article

Crotalphine Modulates Microglia M1/M2 Phenotypes and Induces Spinal Analgesia Mediated by Opioid-Cannabinoid Systems.

International journal of molecular sciences - 30 Sept 2022

Lopes Flavia S R, Giardini Aline C, Sant'Anna Morena B, Kimura Louise F, Bufalo Michelle C, Vigerelli Hugo, Zambelli Vanessa O, Picolo Gisele

Abstract excerpt

Pain is a worldwide public health problem and its treatment is still a challenge since clinically available drugs do not completely reverse chronic painful states or induce undesirable effects. Crotalphine is a 14 amino acids synthetic peptide that induces a potent and long-lasting analgesic effect on acute and chronic pain models, peripherally mediated by the endogenous release of dynorphin A and the...

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Identifiers

PMID: 36232883
DOI: 10.3390/ijms231911571
PMCID: PMC9569646

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