Article

Microglial TLR4 Mediates Post-UTI Chronic Pelvic Pain

2026-08-10

Abstract excerpt

Urinary tract infections (UTIs) are a major risk factor for interstitial cystitis/bladder pain syndrome (IC/BPS), yet the mechanisms driving chronic pelvic pain and associated symptoms remain poorly understood. Here, we investigated the role of microglia and Toll-like receptor 4 (TLR4) in a mouse model of post-UTI chronic pelvic pain (PUPP). Infection with E. coli induced persistent pelvic allodynia that was sign...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e93cc6f-fd07-5962-ade7-bba4a2568e06
DOI: 10.64898/2026.08.04.742321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microglial TLR4 Mediates Post-UTI Chronic Pelvic PainDOI 10.64898/2026.08.04.742321Read

Influence of blood-brain barrier and intestinal barrier on microglial phenotypes: a perspective of clinical and prognostic implications.Semantic proximity Read

The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways.Semantic proximity Read

P2X4R+ microglia drive neuropathic pain.Semantic proximity Read

Temporal Contribution of Myeloid-Lineage TLR4 to the Transition to Chronic Pain: A Focus on Sex DifferencesSemantic proximity Read

Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolutionSemantic proximity Read

TREM2 and Pain Development: An Old Molecule, a New TargetSemantic proximity Read

DUSP1 Promotes Microglial Polarization toward M2 Phenotype in the Medial Prefrontal Cortex of Neuropathic Pain Rats via Inhibition of MAPK Pathway.Semantic proximity Read

Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.Semantic proximity Read

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain.Semantic proximity Read

Innate Transcriptional Networks Activated in Bladder in Response to Uropathogenic Escherichia coli Drive Diverse Biological Pathways and Rapid Synthesis of IL-10 for Defense against Bacterial Urinary Tract InfectionSemantic proximity Read

IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.Semantic proximity Read

Macrophage as a Peripheral Pain Regulator.Semantic proximity Read