Article

Low-frequency genetic variants in GAK enhance Golgi function and protect against Parkinson’s disease

2025-08-15

Abstract excerpt

Genome-wide association studies (GWAS) have contributed significantly to unraveling the genetic bases of complex diseases such as Parkinson’s disease (PD); yet experimental evidence for causation is often elusive. Here, we hypothesized that non-manifesting carriers of a PD-causing mutation in the LRRK2 gene could express genetic modifiers conferring disease protection. Using a pluripotent stem cell-based model, we...

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Literature Corpus work: bb42a729-6ac7-55ee-b717-53cd4926c514
DOI: 10.1101/2025.08.13.25333123

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