Article
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.
PloS one - 1 Jan 2018
Marrone Lara, Bus Christine, Schöndorf David, Fitzgerald Julia Catherine, Kübler Manuela, Schmid Benjamin, Reinhardt Peter, Reinhardt Lydia, Deleidi Michela, Levin Tanya, Meixner Andrea, Klink Barbara, Glatza Michael, Gloeckner Christian Johannes, Gasser Thomas, Sterneckert Jared
Abstract excerpt
Induced pluripotent stem cells (iPSCs) have recapitulated several aspects of Parkinson's disease (PD), but most iPSCs are derived from familial cases, which account for only about 15% of patients. Thus, while the emphasis has justifiably been on using iPSCs to model rare familial cases, models for the most common forms of PD are critically lacking. Here, we report the generation of an iPSC-based model of...
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