Article
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
Molecular neurobiology - 1 Dec 2016
Zhang Jie, Zeng Hanyi, Zhu Lei, Deng Libing, Fang Xin, Deng Xia, Liang Huiting, Tang Chunyan, Cao Xuebing, Lu Yi, Li Jiao, Ren Xiao, Zuo Wenjie, Zhang Xiong, Xu Renshi
Abstract excerpt
The genetic factors about the pathogenesis of sporadic Parkinson's disease (sPD) is not completely clear at present; therefore, we performed a genome-wide association study, high-throughput sequencing analysis (HTPSA) of all cyclin G-associated kinase (GAK) exons, loss-of-function assessment, and sorting intolerant from tolerant analysis of HTPSA data in 250 typical sPD and 250 controls, which found 55 candidate...
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