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Article

Modeling the genetic complexity of Parkinson's disease by targeted genome edition in iPS cells.

Current opinion in genetics & development - 1 Oct 2017

Calatayud Carles, Carola Giulia, Consiglio Antonella, Raya Angel

Abstract excerpt

Patient-specific iPSC are being intensively exploited as experimental disease models. Even for late-onset diseases of complex genetic influence, such as Parkinson's disease (PD), the use of iPSC-based models is beginning to provide important insights into the genetic bases of PD heritability. Here, we present an update on recently reported genetic risk factors associated with PD. We discuss how iPSC technology,...

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Identifiers

PMID: 28759872
DOI: 10.1016/j.gde.2017.06.002

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