Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.

PloS one - 1 Jan 2016

Nagle Michael W, Latourelle Jeanne C, Labadorf Adam, Dumitriu Alexandra, Hadzi Tiffany C, Beach Thomas G, Myers Richard H

Abstract excerpt

Genome-wide association studies (GWAS) have identified the GAK/DGKQ/IDUA region on 4p16.3 among the top three risk loci for Parkinson's disease (PD), but the specific gene and risk mechanism are unclear. Here, we report transcripts containing the 3' clathrin-binding domain of GAK identified by RNA deep-sequencing in post-mortem human brain tissue as having increased expression in PD. Furthermore, carriers of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Chromosomes, Human, Pair 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Intracellular Signaling Peptides and Proteins

Share to Mitochondria

Share to Parkinson Disease

Share to Protein Serine-Threonine Kinases

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 27508417
DOI: 10.1371/journal.pone.0160925
PMCID: PMC4980018

Genes

GAK
DGKQ
IDUA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.PMID 27508417Read ↗

SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in womenSemantic proximity Read ↗

Vesicular Dysfunction and the Pathogenesis of Parkinson’s Disease: Clues From Genetic StudiesSemantic proximity Read ↗

<i>TMEM175, SCARB2</i> and <i>CTSB</i> associations with Parkinson’s disease risk across populationsSemantic proximity Read ↗

Novel variants in genes related to vesicle-mediated-transport modify Parkinson's disease risk.Semantic proximity Read ↗

Inherited Genetic Variation in Parkinson’s Disease: Convergence on Impaired Autophagosome-Lysosome Fusion Through the Altered Expression of mRNA IsoformsSemantic proximity Read ↗

TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populationsSemantic proximity Read ↗

Comparative Transcriptome Analysis in Monocyte-Derived Macrophages of Asymptomatic GBA Mutation Carriers and Patients with GBA-Associated Parkinson's Disease.Semantic proximity Read ↗

Prioritizing Parkinson’s Disease genes using population-scale transcriptomic dataSemantic proximity Read ↗

Machine learning identifies six genetic variants and alterations in the Heart Atrial Appendage as key contributors to PD risk predictivitySemantic proximity Read ↗

Age-Stratified Meta-Transcriptomic Analysis Reveals Early and Core Dysregulated Pathways in Parkinson’s DiseaseSemantic proximity Read ↗

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at Chr16q11.2 and on the MAPT H1 alleleSemantic proximity Read ↗

Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data SetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.