Article
Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.
PloS one - 1 Jan 2012
Lucas Gavin, Lluís-Ganella Carla, Subirana Isaac, Musameh Muntaser D, Gonzalez Juan Ramon, Nelson Christopher P, Sentí Mariano, Schwartz Stephen M, Siscovick David, O'Donnell Christopher J, Melander Olle, Salomaa Veikko, Purcell Shaun, Altshuler David, Samani Nilesh J, Kathiresan Sekar, Elosua Roberto
Abstract excerpt
The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential source of the remaining heritability. Given the potentially large testing burden, we sought to enrich our search space with real interactions by analyzing variants that may be more likely to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.