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Article

Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2023

Deming Yuetiva, Vasiljevic Eva, Morrow Autumn, Miao Jiacheng, Van Hulle Carol, Jonaitis Erin, Ma Yue, Whitenack Vanessa, Kollmorgen Gwendlyn, Wild Norbert, Suridjan Ivonne, Shaw Leslie M, Asthana Sanjay, Carlsson Cynthia M, Johnson Sterling C, Zetterberg Henrik, Blennow Kaj, Bendlin Barbara B, Lu Qiongshi, Engelman Corinne D

Abstract excerpt

INTRODUCTION: Apolipoprotein E (APOE) ε4-carrier status or ε4 allele count are included in analyses to account for the APOE genetic effect on Alzheimer's disease (AD); however, this does not account for protective effects of APOE ε2 or heterogeneous effect of ε2, ε3, and ε4 haplotypes. METHODS: We leveraged results from an autopsy-confirmed AD study to generate a weighted risk score for APOE (APOE-npscore). We...

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PMID: 36795776
DOI: 10.1002/alz.12990
PMCID: PMC10427737

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