Article

A single short reprogramming early in life improves fitness and increases lifespan in old age

2021-05-14

Abstract excerpt

Forced and maintained expression of four transcription factors OCT4, SOX2, KLF4 and c-MYC (OSKM), can reprogram somatic cells into induced Pluripotent Stem Cells (iPSCs) and a limited OSKM induction is able to rejuvenate the cell physiology without changing the cell identity. We therefore sought to determine if a burst of OSKM might improve tissue fitness and delay age-related pathologies in a whole animal. For th...

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Literature Corpus work: bb23d1d7-7b3a-5c05-b708-874450b71214
DOI: 10.1101/2021.05.13.443979

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