Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging

11 Sept 2024

Abstract excerpt

Aging is a complex multifactorial process associated with epigenome dysregulation, increased cellular senescence, and decreased rejuvenation capacity. Short-term cyclic expression of octamer-binding transcription factor 4 ( Oct4 ), sex-determining region Y-box 2 ( Sox2 ), Kruppel-like factor 4 ( Klf4 ), and cellular myelocytomatosis oncogene ( cMyc ) ( OSKM ) in wild-type mice improves health but fails to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Structure and Function
Share to PARP inhibition in cancer therapy
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39259812
DOI: 10.1126/scitranslmed.adg1777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of agingPMID 39259812Read ↗

Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged MiceSemantic proximity Read ↗

Conserved biological processes in partial cellular reprogramming: Relevance to aging and rejuvenationSemantic proximity Read ↗

Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identitySemantic proximity Read ↗

Conserved Biological Processes in Partial Cellular Reprogramming: A Comprehensive ReviewSemantic proximity Read ↗

Adult Stem Cells and Diseases of AgingSemantic proximity Read ↗

Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cellsSemantic proximity Read ↗

Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during AgingSemantic proximity Read ↗

The involvement of human endogenous retroviruses K (HERV-K) in aging processes via induction of inflammationSemantic proximity Read ↗

Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cellsSemantic proximity Read ↗

Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profilingSemantic proximity Read ↗

Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging modelsSemantic proximity Read ↗

Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend LifespanSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.