Article

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

2021-01-17

Abstract excerpt

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue dysfunction and disease. At the cellular level, ageing is associated with reduced function, altered gene expression and a perturbed epigenome. Somatic cell reprogramming, the process of converting somatic cells to induced pluripotent stem cells (iPSCs), can reverse these age-associated changes. However, during iPSC reprogra...

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Literature Corpus work: 280a9fcd-627c-574d-b3e1-8a6fc84ce923
DOI: 10.1101/2021.01.15.426786

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